![]() We seek to quantitatively characterize alterations in metabolic activities of cancer cells subject to acute and chronic acidosis, and identify key metabolic pathways that allow survival and proliferation of cancer cells in an acidic environment. Cancer cells exposed to low extracellular pH adapt to this metabolic stress over time, and the adaptation is often associated with increased metastasis potential and chemoresistance. Understanding metabolic adaptation in cancer cells in acidic environmentsĪs a result of insufficient perfusion and high glycolytic activity, the microenvironment of solid tumors is often acidic. The currently focuses of our lab are the following: To study this, we combine systems biology approaches, especially fluxomics and metabolomics, with computational modeling and biochemical and genetic techniques. The overarching goal of our research is to understand how mammalian cellular metabolism is reprogrammed in response to changes in the environment and cellular state, and how activities in key metabolic pathways can in turn affect cell function. ![]() Dynamic reprogramming of metabolism enables cells to meet metabolic needs associated with specific cellular states and cellular functions (such as supporting proliferation or activating immune function), and adapt to changes in the environment. ![]() metabolic flux) through the pathways varies greatly. While the architecture of metabolic networks is defined by the genome, actual metabolic activity (i.e. Mammalian cellular metabolism is a dynamic process that consists of thousands of interconnected reactions and regulatory interactions. ![]()
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